What it is
Bones and teeth get their strength from minerals laid down in a framework of protein. The enzyme that is lacking in hypophosphatasia clears away a substance that would otherwise stop these minerals from settling, so without enough of it the framework stays soft. Bones can bend under the puppy's weight, and the roots of the teeth are not held firmly in the jaw.
The condition is inherited and present from birth. How strongly it affects a dog can vary widely, from a puppy that struggles to grow and move to a dog whose main sign is losing teeth early.
Day to day, a puppy with fragile bones needs a home where falls are less likely: non-slip floors, no jumping down from heights, and gentle play instead of rough games with bigger dogs. Chewing may be uncomfortable when teeth are loose.
Signs you may notice
You may notice a puppy that grows more slowly, has bowed legs, limps or is reluctant to move, and loses teeth earlier than it should. Some puppies break bones after only a minor knock.
When to see a vet
Book a visit if a puppy grows slowly, its legs look bowed, it limps or it loses teeth earlier than expected. A puppy that cries out and will not use a leg after a minor knock should be seen the same day.
This is general information, not veterinary advice. For your own dog's health, tests and treatment, see a vet.