What it is
Inside every cell, sugar is broken down in two stages. The first gives a little energy quickly; the second, which takes place in the cell's power stations, the mitochondria, gives far more. Pyruvate dehydrogenase is the enzyme that hands the fuel from the first stage to the second. When it is missing or weak, cells are stuck with the quick but wasteful route: energy runs short, lactic acid builds up, and the muscles, which burn energy fastest, feel it first.
The disorder is inherited, and signs show up early in life, when a young dog starts to run and play hard. The weakness is brought on by exertion and eases with rest.
Life with it is a matter of pace. Calm walks, sniffing and short games suit such a dog far better than long runs or hard training, and stopping at the first sign of tiredness spares it the struggle.
Signs you may notice
- Tires unusually fast
- Heavy panting after a short run
- Staggers or wobbles
- Lies down and won't go on
- Collapse or fainting
You may notice the dog tiring unusually fast, panting heavily after a short run, staggering, or lying down and refusing to go on. If a dog collapses or faints, it needs a vet immediately.
When to see a vet
Book a visit if a young dog tires far sooner than it should or keeps stopping on walks. If your dog collapses or faints, a vet is needed immediately.
This is general information, not veterinary advice. For your own dog's health, tests and treatment, see a vet.